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Comment
. 2009;13(4):170.
doi: 10.1186/cc7970. Epub 2009 Jul 27.

Macrophage migration inhibitory factor, infection, the brain, and corticosteroids

Madelijn Geldhoff  1 , Barry B Mook-Kanamori, Diederik van de Beek
Affiliations
Comment

Macrophage migration inhibitory factor, infection, the brain, and corticosteroids

Madelijn Geldhoff et al. Crit Care. 2009.

Abstract

Bacterial meningitis is a complex disorder in which injury is caused, in part, by the causative organism and, in part, by the host's own inflammatory response. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and a neuro-endocrine mediator that might play a role in pneumococcal meningitis. Here, we discuss the role of MIF in infection, the brain, and corticosteroids and conclude that experimental meningitis studies have to determine whether MIF is a potential target for adjunctive therapy in pneumococcal meningitis.

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References

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