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. 2009 Dec;27(12):2386-93.
doi: 10.1097/HJH.0b013e3283310f7e.

Retinal vessel diameters and risk of hypertension: the Multiethnic Study of Atherosclerosis

Ryo Kawasaki  1 , Ning Cheung, Jie Jin Wang, Ronald Klein, Barbara Ek Klein, Mary Frances Cotch, A Richey Sharrett, Steven Shea, Fm Amirul Islam, Tien Y Wong
Affiliations

Retinal vessel diameters and risk of hypertension: the Multiethnic Study of Atherosclerosis

Ryo Kawasaki et al. J Hypertens. 2009 Dec.

Abstract

Objective: To describe the prospective relationship of retinal vessel diameters with risk of hypertension in a multiethnic population-based cohort.

Methods: The Multi-Ethnic Study of Atherosclerosis is a population-based study of subclinical cardiovascular disease among white, African-American, Hispanic, and Chinese American adults aged 45-84 years. Retinal vessel diameters were measured using a standardized imaging software at the second examination (considered baseline in this analysis) and summarized as the central retinal artery/vein equivalent. Presence of retinopathy and retinal focal arteriolar narrowing and arteriovenous nicking was assessed by trained graders. Incidence of hypertension was defined among participants at risk as systolic blood pressure at least 140 mmHg, diastolic blood pressure at least 90 mmHg, or use of an antihypertensive medication.

Results: Of the initial 6237 participants at baseline, 2583 were at risk of hypertension. After 3.2 +/- 0.5 years of follow-up, 448 (17.3%) participants developed hypertension. After adjusting for age, sex, race/ethnicity, the average of mean arterial blood pressure in the first and second examination, and other vascular risk factors, persons with narrower retinal arteriolar diameter and wider venular diameter at baseline were more likely to develop hypertension [odds ratio per SD decrease in central retinal artery equivalent 1.20, 95% confidence intervals 1.02, 1.42; and odds ratio per SD increase in central retinal vein equivalent 1.18, 95% confidence interval 1.02, 1.37]. Persons with focal arteriolar narrowing were also more likely to develop hypertension (odds ratio 1.80, 95% confidence interval 1.09, 2.97).

Conclusion: Findings from this multiethnic population confirm that narrower retinal arteriolar diameter and wider venular diameter are associated with the development of hypertension independent of traditional risk factors.

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Figures

Fig. 1
Fig. 1
Incidence of hypertension (%) by age groups and vessel diameters (adjusted for sex and race). CRAE, central retinal artery equivalent; CRVE, central retinal vein equivalent; 1Q–4Q, lowest to highest quartiles.
Fig. 2
Fig. 2
Incidence of hypertension (%) by deciles of central retinal artery equivalent.
See this image and copyright information in PMC

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References

    1. Feihl F, Liaudet L, Waeber B, Levy BI. Hypertension: a disease of the microcirculation? Hypertension. 2006;48:1012–1017. - PubMed
    1. Folkow B. Physiological aspects of primary hypertension. Physiol Rev. 1982;62:347–504. - PubMed
    1. Rizzoni D, Castellano M, Porteri E, Bettoni G, Muiesan ML, Agabiti-Rosei E. Vascular structural and functional alterations before and after the development of hypertension in SHR. Am J Hypertens. 1994;7:193–200. - PubMed
    1. Norrelund H, Christensen KL, Samani NJ, Kimber P, Mulvany MJ, Korsgaard N. Early narrowed afferent arteriole is a contributor to the development of hypertension. Hypertension. 1994;24:301–308. - PubMed
    1. Levy BI, Ambrosio G, Pries AR, Struijker-Boudier HA. Microcirculation in hypertension: a new target for treatment? Circulation. 2001;104:735–740. - PubMed

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