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. 2009 Sep;9(9):662-8.
doi: 10.1038/nri2619. Epub 2009 Aug 14.

The precursors of memory: models and controversies

Rafi Ahmed  1 , Michael J Bevan, Steven L Reiner, Douglas T Fearon
Affiliations

The precursors of memory: models and controversies

Rafi Ahmed et al. Nat Rev Immunol. 2009 Sep.

Abstract

The adaptive immune system has evolved a unique capacity to remember a pathogen through the generation of memory T cells, which rapidly protect the host in the event of reinfection. How memory T cells develop and the relationship between effector and memory T cells has been actively debated in the literature for many years and several models have been proposed to explain the divergent developmental fates of T cell progeny. Here, Nature Reviews Immunology asks four leading researchers in the field to provide their thoughts and opinions on the ontogeny of memory T cells and its implications for vaccine design.

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