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Case Reports
. 2009 Sep 15;49(6):e62-5.
doi: 10.1086/605532.

Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-gamma receptor 1 deficiency

Donald C Vinh  1 , Fares Masannat, Robert B Dzioba, John N Galgiani, Steven M Holland
Affiliations
Case Reports

Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-gamma receptor 1 deficiency

Donald C Vinh et al. Clin Infect Dis. .

Abstract

Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-gamma receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-gamma axis appears to be critical for control of coccidioidomycosis.

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Conflict of interest statement

Potential conflicts of interest. All authors: no conflicts.

Figures

Figure 1
Figure 1
Timeline graphic illustrating the course of infections and correlation with coccidioidal antibody titers. Coccidioidal serology was performed at University of California, Davis, California by complement fixation (from age 12 to 15) and at the Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona by quantitative immunodiffusion (from age 21 to present) as previously described [22].
See this image and copyright information in PMC

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