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Review
. 2009;60(1):5-11.
doi: 10.1159/000234811. Epub 2009 Aug 14.

Epigenetic profiling in schizophrenia and major mental disorders

Kazuya Iwamoto  1 , Tadafumi Kato
Affiliations
Review

Epigenetic profiling in schizophrenia and major mental disorders

Kazuya Iwamoto et al. Neuropsychobiology. 2009.

Abstract

Epigenetic alterations such as DNA methylation and histone modifications are important in the etiology or pathophysiology of mental disorders. Here, we review recent studies on the relationship between DNA methylation and major mental disorders. We will focus on the role of DNA methylation in postmitotic neurons, intra- and interindividual variations in DNA methylation, the possible involvement of methionine metabolism pathways, and candidate and genome-wide DNA methylation as they relate to mental disorders.

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