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. 2009 Sep;15(9):1013-5.
doi: 10.1038/nm.1995. Epub 2009 Aug 16.

Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

Roberta Caruso  1 , Elisabetta Botti, Massimiliano Sarra, Maria Esposito, Carmine Stolfi, Laura Diluvio, Maria Laura Giustizieri, Valentina Pacciani, Annamaria Mazzotta, Elena Campione, Thomas T Macdonald, Sergio Chimenti, Francesco Pallone, Antonio Costanzo, Giovanni Monteleone
Affiliations

Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

Roberta Caruso et al. Nat Med. 2009 Sep.

Abstract

T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis.

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