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. 2009 Sep 9;131(35):12552-3.
doi: 10.1021/ja905908z.

Rhodium-catalyzed highly enantioselective direct intermolecular hydroacylation of 1,1-disubstituted alkenes with unfunctionalized aldehydes

Yu Shibata  1 , Ken Tanaka
Affiliations

Rhodium-catalyzed highly enantioselective direct intermolecular hydroacylation of 1,1-disubstituted alkenes with unfunctionalized aldehydes

Yu Shibata et al. J Am Chem Soc. .

Abstract

We have established that a cationic rhodium(I)/(R,R)-QuinoxP* complex catalyzes the highly enantioselective direct intermolecular hydroacylation of alpha-substituted acrylamides with unfunctionalized aliphatic aldehydes to yield the corresponding gamma-ketoamides in high yields with excellent ee values.

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