doi: 10.1016/j.devcel.2009.07.020.
LIN28 lets BLIMP1 take the right course
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- PMID: 19686677
- DOI: 10.1016/j.devcel.2009.07.020
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LIN28 lets BLIMP1 take the right course
Dev Cell.
2009 Aug.
Free article
Abstract
The transcription factor BLIMP1 is a master regulator of primordial germ cell (PGC) specification and is suppressed by the microRNA let-7. In a recent issue of Nature, West and colleagues use a unique in vitro ES cell differentiation strategy to show that LIN28 is an essential regulator of PGC formation through inhibition of let-7 maturation and consequential induction of BLIMP1.
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