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. 2009 Aug;17(2):160-1.
doi: 10.1016/j.devcel.2009.07.020.

LIN28 lets BLIMP1 take the right course

Martin M Matzuk  1
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Free article

LIN28 lets BLIMP1 take the right course

Martin M Matzuk. Dev Cell. 2009 Aug.
Free article

Abstract

The transcription factor BLIMP1 is a master regulator of primordial germ cell (PGC) specification and is suppressed by the microRNA let-7. In a recent issue of Nature, West and colleagues use a unique in vitro ES cell differentiation strategy to show that LIN28 is an essential regulator of PGC formation through inhibition of let-7 maturation and consequential induction of BLIMP1.

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