A novel antifungal anthraquinone from seeds of Aegle marmelos Correa (family Rutaceae)

Abstract

A new anthraquinone, 1-methyl-2-(3'-methyl-but-2'-enyloxy)-anthraquinone (1) has been isolated from seeds of Aegle marmelos Correa and was characterized on the basis of spectral analysis (UV, IR, 1H NMR, 13C NMR, 2D NMR and mass spectroscopy). The compound exhibited significant antifungal activity against pathogenic strains of Aspergillus species and Candida albicans in disc diffusion assay (MIC value of 6.25 microg/disc), microbroth dilution and percent spore germination inhibition assays (MIC value of 31.25-62.5 microg/ml).