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. 2011:2011:212641.
doi: 10.1093/ecam/nep108. Epub 2011 Jan 3.

Review of Pharmacological Effects of Antrodia camphorata and Its Bioactive Compounds

Madamanchi Geethangili  1 , Yew-Min Tzeng
Affiliations

Review of Pharmacological Effects of Antrodia camphorata and Its Bioactive Compounds

Madamanchi Geethangili et al. Evid Based Complement Alternat Med. 2011.

Abstract

Antrodia camphorata is a unique mushroom of Taiwan, which has been used as a traditional medicine for protection of diverse health-related conditions. In an effort to translate this Eastern medicine into Western-accepted therapy, a great deal of work has been carried out on A. camphorata. This review discusses the biological activities of the crude extracts and the main bioactive compounds of A. camphorata. The list of bioactivities of crude extracts is huge, ranging from anti-cancer to vasorelaxation and others. Over 78 compounds consisting of terpenoids, benzenoids, lignans, benzoquinone derivatives, succinic and maleic derivatives, in addition to polysaccharides have been identified. Many of these compounds were evaluated for biological activity. Many activities of crude extracts and pure compounds of A. camphorata against some major diseases of our time, and thus, a current review is of great importance. It is concluded that A. camphorata can be considered as an efficient alternative phytotherapeutic agent or a synergizer in the treatment of cancer and other immune-related diseases. However, clinical trails of human on A. camphorata extracts are limited and those of pure compounds are absent. The next step is to produce some medicines from A. camphorata, however, the production may be hampered by problems related to mass production.

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Figures

Figure 1
Figure 1
Antrodia camphorata from solid-state cultivation of wood. (a) Mycelium from 12-month-old sample. (b) Fruiting bodies from 18-month-old sample. (c) Fruiting bodies from 24-month-old sample. (d) Fruiting bodies from multiple years grown sample.
Figure 2
Figure 2
Isolated constituents from A. camphorata. (a) Sesqui- and diterpenoids. (b) Ergostane type triterpenoids. (c) Lanostane-type triterpenoids. (d) Triterpenoid related compounds. (e) Benzenoids. (f) Lignans and benzoquinone derivatives. (g) Succinic and maleic derivatives. (h) Miscellaneous compounds.
Figure 2
Figure 2
Isolated constituents from A. camphorata. (a) Sesqui- and diterpenoids. (b) Ergostane type triterpenoids. (c) Lanostane-type triterpenoids. (d) Triterpenoid related compounds. (e) Benzenoids. (f) Lignans and benzoquinone derivatives. (g) Succinic and maleic derivatives. (h) Miscellaneous compounds.
Figure 2
Figure 2
Isolated constituents from A. camphorata. (a) Sesqui- and diterpenoids. (b) Ergostane type triterpenoids. (c) Lanostane-type triterpenoids. (d) Triterpenoid related compounds. (e) Benzenoids. (f) Lignans and benzoquinone derivatives. (g) Succinic and maleic derivatives. (h) Miscellaneous compounds.
See this image and copyright information in PMC

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