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. 2009 Oct;53(10):4511-3.
doi: 10.1128/AAC.00784-09. Epub 2009 Aug 17.

Regional dissemination of KPC-producing Klebsiella pneumoniae

Brandon Kitchel  1 , Daniel R Sundin, Jean B Patel
Affiliations

Regional dissemination of KPC-producing Klebsiella pneumoniae

Brandon Kitchel et al. Antimicrob Agents Chemother. 2009 Oct.

Abstract

Production of a Klebsiella pneumoniae carbapenemase (KPC) is the most common mechanism of carbapenem resistance in the United States; however, until now, KPC-producing isolates have not been found in western Michigan. Molecular typing of two KPC-producing K. pneumoniae isolates from Michigan showed their similarity to other Midwestern isolates. They were also unrelated to the dominant sequence type observed throughout the United States, multilocus sequence type 258. This could represent regional dissemination of another KPC-producing K. pneumoniae strain.

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Figures

FIG. 1.
FIG. 1.
Dendrogram based on similarity of PFGE patterns. Isolates shaded in gray (n = 8) make up a branch of the dendrogram representing related K. pneumoniae isolates that have disseminated in the Midwestern United States, thus far identified in Illinois, Missouri, and now Michigan. The other isolates (n = 20) were selected to represent the CDC's PFGE database of KPC-producing K. pneumoniae, consisting of over 400 isolates, primarily of ST 258. KPC subtyping was determined via bidirectional sequencing of the blaKPC gene by using previously described primers (13). MLST results marked with an asterisk indicate isolates that were not typed by MLST but demonstrated PFGE patterns closely related to those of known ST 14 isolates.
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