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Review
. 2010 Feb;456(2):167-79.
doi: 10.1007/s00428-009-0815-x. Epub 2009 Aug 18.

Well-differentiated and dedifferentiated liposarcomas

Jean-Michel Coindre  1 , Florence Pédeutour, Alain Aurias
Affiliations
Review

Well-differentiated and dedifferentiated liposarcomas

Jean-Michel Coindre et al. Virchows Arch. 2010 Feb.

Abstract

Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14-15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.

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