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Review
. 2009 Nov;66(21):3399-402.
doi: 10.1007/s00018-009-0127-y. Epub 2009 Aug 18.

Mylip makes an Idol turn into regulation of LDL receptor

Dan Lindholm  1 , Beat C Bornhauser, Laura Korhonen
Affiliations
Review

Mylip makes an Idol turn into regulation of LDL receptor

Dan Lindholm et al. Cell Mol Life Sci. 2009 Nov.

Abstract

High blood low-density-lipoprotein (LDL) cholesterol is a serious health problem among an increased number of patients in the Western world. Statins and other cholesterol lowering drugs have proven to be beneficial as therapy but are not optimal and show adverse effects in some patients. The LDL receptor is a crucial determinant of cholesterol metabolism in the body and amenable for drug interventions. Novel insights into the physiology of this receptor come from studies on the ubiquitination and degradation of LDL receptor by the ubiquitin ligase Mylip/Idol that is induced in cells by the nuclear receptor, LXR. This may open up new possibilities in the future to influence LDL receptor levels and cholesterol metabolism pharmacologically in various diseases.

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References

    1. Zelcer N, Hong C, Boyadjian R, Tontonoz P. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science. 2009;325:100–104. doi: 10.1126/science.1168974. - DOI - PMC - PubMed
    1. Brown MS, Goldstein JL. Receptor-mediated endocytosis: insights from the lipoprotein receptor system. Proc Nat Acad Sci USA. 1979;76:3330–3337. doi: 10.1073/pnas.76.7.3330. - DOI - PMC - PubMed
    1. Goldstein JL, Brown MS. The LDL receptor. Arterioscler Thromb Vasc Biol. 2009;29:431–438. doi: 10.1161/ATVBAHA.108.179564. - DOI - PMC - PubMed
    1. Nabel EG. Cardiovascular disease. N Engl J Med. 2003;349:60–72. doi: 10.1056/NEJMra035098. - DOI - PubMed
    1. Knopp RH. Drug treatment of lipid disorders. N Engl J Med. 1999;341:498–511. doi: 10.1056/NEJM199908123410707. - DOI - PubMed

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