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Review
. 2009 Aug;6(4):331-6.
doi: 10.2174/156720509788929264.

Clinical trajectories and biological features of primary progressive aphasia (PPA)

E J Rogalski  1 , M M Mesulam
Affiliations
Review

Clinical trajectories and biological features of primary progressive aphasia (PPA)

E J Rogalski et al. Curr Alzheimer Res. 2009 Aug.

Abstract

Primary Progressive Aphasia (PPA) is a neurodegenerative syndrome characterized by a gradual dissolution of language, but relative sparing of other cognitive domains during the initial stages of the disease. Research has led to substantial progress in understanding the clinical characteristics, genetics, and neuropathology of this syndrome. This article reviews the clinical criteria for diagnosing PPA, discusses the utility of defining the mild cognitive impairment (MCI) stage of PPA, and highlights some of the more recent research advances particularly in the area of pathology and genetics.

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Figures

Fig. (1)
Fig. (1)
Clinical trajectory of PPA. Not all patients progress to the PPA+ stage.
See this image and copyright information in PMC

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