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Review
. 2009 Aug;9(9):1102-12.
doi: 10.2174/138955709788922656.

ABC transporters as potential targets for modulation of drug resistance

L Gatti  1 , G L Beretta, G Cossa, F Zunino, P Perego
Affiliations
Review

ABC transporters as potential targets for modulation of drug resistance

L Gatti et al. Mini Rev Med Chem. 2009 Aug.

Abstract

ATP binding cassette transporters are implicated in multidrug resistant phenotypes of tumor cells and may be cancer stem cell markers. Inhibitors of drug efflux pumps represent an emerging group of potentially useful agents for the improvement of antitumor therapy. Here we provide an overview of drug transporter functions and modulation.

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