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. 2009 Oct;64(4):797-800.
doi: 10.1093/jac/dkp300. Epub 2009 Aug 18.

In vitro antibacterial activities of a novel oxazolidinone, OCID0050

Maneesh Paul-Satyaseela  1 , Shakti Singh Solanki, Devarajan Sathishkumar, Thirunavukkarasu Bharani, Vijayan Magesh, Sriram Rajagopal
Affiliations

In vitro antibacterial activities of a novel oxazolidinone, OCID0050

Maneesh Paul-Satyaseela et al. J Antimicrob Chemother. 2009 Oct.

Abstract

Objectives: In the pursuit of developing a second-generation oxazolidinone, we have identified OCID0050 as a novel oxazolidinone with enhanced activity against bacterial strains resistant to methicillin, vancomycin and linezolid.

Methods: MIC and MBC determinations were performed according to CLSI guidelines. Linezolid-resistant bacterial strains were generated in-house; inoculum effect, pH effect and kill kinetics experiments were performed as per standard protocols.

Results and conclusions: OCID0050 demonstrated better inhibitory potency against many of the tested clinically significant strains by generally showing 2-4-fold lower MICs than linezolid. In addition, it has higher inhibitory activity against linezolid-resistant strains.

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