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Comment
. 2009 Sep;5(9):607-8.
doi: 10.1038/nchembio0909-607.

Protease dimer formation disrupted

Jean Chmielewski  1
Affiliations
Comment

Protease dimer formation disrupted

Jean Chmielewski. Nat Chem Biol. 2009 Sep.

Abstract

A small-molecule inhibitor of the obligate dimeric protease of human Kaposi's sarcoma-associated herpesvirus was identified. The agent functions by a "monomer trap" mechanism in which the compound binds to a partially unfolded monomer and disrupts the formation of the enzymatically active protease dimer.

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