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. 2007 Feb 7:1:215-25.

Biomarkers in cervical cancer

Eun-Kyoung Yim  1 , Jong-Sup Park
Affiliations

Biomarkers in cervical cancer

Eun-Kyoung Yim et al. Biomark Insights. .

Abstract

Cervical cancer, a potentially preventable disease, remains the second most common malignancy in women worldwide. Human papillomavirus (HPV) is the single most important etiological agent in cervical cancer, contributing to neoplastic progression through the action of viral oncoproteins, mainly E6 and E7. Cervical screening programs using Pap smear testing have dramatically improved cervical cancer incidence and reduced deaths, but cervical cancer still remains a global health burden. The biomarker discovery for accurate detection and diagnosis of cervical carcinoma and its malignant precursors (collectively referred to as high-grade cervical disease) represents one of the current challenges in clinical medicine and cytopathology.

Keywords: Cervical cancer; Human papillomavirus (HPV); biomarker.

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Figures

Figure 1
Figure 1
Cellular binding partners for HPV E6.
Figure 2
Figure 2
Cellular binding partners for HPV E7.
See this image and copyright information in PMC

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