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Review
. 2009 Sep;10(9):929-32.
doi: 10.1038/ni0909-929.

From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development

Anne O'Garra  1 , Kenneth M Murphy
Affiliations
Review

From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development

Anne O'Garra et al. Nat Immunol. 2009 Sep.

Abstract

The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.

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