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Comparative Study
. 2009 Nov;76(9):984-90.
doi: 10.1038/ki.2009.291. Epub 2009 Aug 19.

Survival and hospitalization among patients using nocturnal and short daily compared to conventional hemodialysis: a USRDS study

Kirsten L Johansen  1 , Rebecca Zhang, Yijian Huang, Shu-Cheng Chen, Christopher R Blagg, Alexander S Goldfarb-Rumyantzev, Chistopher D Hoy, Robert S Lockridge Jr, Brent W Miller, Paul W Eggers, Nancy G Kutner
Affiliations
Comparative Study

Survival and hospitalization among patients using nocturnal and short daily compared to conventional hemodialysis: a USRDS study

Kirsten L Johansen et al. Kidney Int. 2009 Nov.

Abstract

We estimated the survival and hospitalization among frequent hemodialysis users in comparison to those patients undergoing thrice-weekly conventional hemodialysis. All patients had similar characteristics and medical histories. In this cohort study of frequent hemodialysis users and propensity score-matched controls, the collaborating clinicians identified 94 patients who used nocturnal hermodialysis (NHD) and 43 patients who used short-duration daily hemodialysis (SDHD) for a minimum of 60 days. Ten propensity score-matched control patients for each NHD and SDHD patient were identified from the United States Renal Data System database. Primary outcomes were risk for all-cause mortality and risk for the composite outcome of mortality or major morbid event (acute myocardial infarction or stroke) estimated using Cox proportional hazards models. Risks for all-cause, cardiovascular-related, infection-related, and vascular access-related hospital admissions were also studied. Nocturnal hemodialysis was associated with significant reductions in mortality risk and risk for mortality or major morbid event when compared to conventional hemodialysis. There was a reduced but non-significant risk of death for patients using SDHD compared to controls. All-cause and specific hospitalizations did not differ significantly between NHD and SDHD patients and their matched control cohorts. Our study suggests that NHD may improve patient survival.

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Figures

Figure 1
Figure 1. Kaplan–Meier analysis of nocturnal hemidiolysis (NHD) therapy patient and conventional hemodialosis (CHD) control survival from baseline
Patient survival was analyzed as time until death; observations were censored at the end of follow-up or transplantation.
Figure 2
Figure 2. Kaplan–Meier analysis of short-duration daily hemodialysis (SDHD) therapy patient and conventional hemodialysis (CHD) control survival from baseline
Patient survival was analyzed as time until death; observations were censored at the end of follow-up or transplantation.
See this image and copyright information in PMC

References

    1. Chertow GM. ‘Wishing don't make it so’—why we need a randomized clinical trial of high-intensity hemodialysis. J Am Soc Nephrol. 2001;12:2850–2853. - PubMed
    1. Home Dialysis Central: Home Dialysis Central reports tremendous 4-year growth in #s of home programs. Home Dialysis Central Update. 2008;5(3) available at www.homedialysis.org.
    1. Mohr PE, Neumann PJ, Franco SJ, et al. The case for daily dialysis: its impact on costs and quality of life. Am J Kidney Dis. 2001;37:777–789. - PubMed
    1. Mohr PE. The economics of daily dialysis. Adv Ren Replace Ther. 2001;8:273–279. - PubMed
    1. Ting GO, Kjellstrand C, Freitas T, et al. Long-term study of high-comorbidity ESRD patients converted from conventional to short daily hemodialysis. Am J Kidney Dis. 2003;42:1020–1035. - PubMed

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