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. 2009 Oct 1;200(7):1054-8.
doi: 10.1086/605644.

APOBEC3B deletion and risk of HIV-1 acquisition

Ping An  1 , Randall Johnson, John Phair, Gregory D Kirk, Xiao-Fang Yu, Sharyne Donfield, Susan Buchbinder, James J Goedert, Cheryl A Winkler
Affiliations

APOBEC3B deletion and risk of HIV-1 acquisition

Ping An et al. J Infect Dis. .

Abstract

The human APOBEC3 family of cytidine deaminases provides intrinsic immunity to retroviral infection. A naturally occurring 29.5-kb deletion removes the entire APOBEC3B gene. We examined the impact of the APOBEC3B gene deletion in >4000 individuals from 5 human immunodeficiency virus type 1 (HIV-1) natural history cohorts. The hemizygous genotype had no effect on either acquisition of HIV-1 infection or progression to AIDS. However, the homozygous deletion was significantly associated with unfavorable outcomes for HIV-1 acquisition (odds ratio, 7.37; P= .024), progression to AIDS (relative hazard, 4.01; P=. 03), and viral set point (P= .04). These findings suggest that the loss of APOBEC3B may increase host susceptibility to HIV-1 acquisition and progression to AIDS and warrant further study.

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Conflict of interest statement

Authors declare no potential conflict of interest.

Comment in

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