Comment
doi: 10.1016/j.immuni.2009.08.002.
LAT polices T cell activation
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- PMID: 19699166
- DOI: 10.1016/j.immuni.2009.08.002
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Comment
LAT polices T cell activation
Immunity.
.
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Abstract
Mutations in the adaptor molecule LAT can lead to autoimmunity. In this issue of Immunity, Mingueneau et al. (2009) describe how this may not be a failure of central tolerance.
Comment on
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Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.Immunity. 2009 Aug 21;31(2):197-208. doi: 10.1016/j.immuni.2009.05.013. Epub 2009 Aug 13. Immunity. 2009. PMID: 19682930
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