Gammadelta T cell receptors without a job
- PMID: 19699169
- DOI: 10.1016/j.immuni.2009.08.004
Gammadelta T cell receptors without a job
Abstract
In this issue of Immunity, the studies by Sutton et al. (2009) and Martin et al. (2009) indicate that gammadelta T cells are innate cells that rapidly produce interleukin (IL)-17 in response to cytokines or pathogens without the need for T cell receptor engagement.
Comment on
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Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals.Immunity. 2009 Aug 21;31(2):321-30. doi: 10.1016/j.immuni.2009.06.020. Epub 2009 Aug 13. Immunity. 2009. PMID: 19682928
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Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.Immunity. 2009 Aug 21;31(2):331-41. doi: 10.1016/j.immuni.2009.08.001. Epub 2009 Aug 13. Immunity. 2009. PMID: 19682929
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