Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2009 Sep;15(7):561-4.
doi: 10.1016/j.cardfail.2009.04.004. Epub 2009 Jun 13.

Heart failure with a normal ejection fraction (HFNEF): embracing complexity

Mathew S Maurer
Editorial

Heart failure with a normal ejection fraction (HFNEF): embracing complexity

Mathew S Maurer. J Card Fail. 2009 Sep.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Panel A: Model of Chronic Disease such as HFNEF, in which risk factors that cause/contribute to syndrome are characterized by early age of onset, progression at various rates, and pass a symptomatic threshold at which time a clinical diagnosis is made. Factors such as a prolonged QRS are adverse prognostic markers while effective interventions alter the progression in a favorable manner. Panel B and C: Compression of Morbidity in HFNEF dan be realized in which by delaying or eliminating contributing/causal factors, the period of adult vigor prior to infirmity is prolonged in the panel C as compared with B. (Modified from Fries JF20)
See this image and copyright information in PMC

Comment on

References

    1. Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med. 2006 July 20;355(3):251–259. - PubMed
    1. Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease. Circulation. 2003 January 7;107(1):139–146. - PubMed
    1. Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease. Circulation. 2003 January 21;107(2):346–354. - PubMed
    1. Burkhoff D, Maurer MS, Packer M. Heart failure with a normal ejection fraction: is it really a disorder of diastolic function? Circulation. 2003 February 11;107(5):656–658. - PubMed
    1. Maurer MS, King DL, El-Khoury RL, Packer M, Burkhoff D. Left heart failure with a normal ejection fraction: identification of different pathophysiologic mechanisms. J Card Fail. 2005 April;11(3):177–187. - PubMed