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Review
. 1990 Apr 21;335(8695):939-40.
doi: 10.1016/0140-6736(90)91000-z.

Hypothesis: does breast cancer originate in utero?

D Trichopoulos  1
Affiliations
Review

Hypothesis: does breast cancer originate in utero?

D Trichopoulos. Lancet. .

Abstract

Factors that increase the risk of cancer during adult life may also increase the risk of cancer when they act in utero (eg, ionising radiation and diethylstilboestrol in human beings and chemicals in animals). The existing empirical data seem to be compatible with the hypothesis that increased concentrations of oestrogens in pregnancy increase the probability of future occurrence of breast cancer in daughters.

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