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Review
. 2009 Oct;19(5):566-72.
doi: 10.1016/j.sbi.2009.07.014. Epub 2009 Aug 21.

Recent developments in phasing and structure refinement for macromolecular crystallography

Paul D Adams  1 , Pavel V Afonine, Ralf W Grosse-Kunstleve, Randy J Read, Jane S Richardson, David C Richardson, Thomas C Terwilliger
Affiliations
Review

Recent developments in phasing and structure refinement for macromolecular crystallography

Paul D Adams et al. Curr Opin Struct Biol. 2009 Oct.

Abstract

Central to crystallographic structure solution is obtaining accurate phases in order to build a molecular model, ultimately followed by refinement of that model to optimize its fit to the experimental diffraction data and prior chemical knowledge. Recent advances in phasing and model refinement and validation algorithms make it possible to arrive at better electron density maps and more accurate models.

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Figures

Figure 1
Figure 1
Overview of the crystallographic structure solution process for macromolecules.
See this image and copyright information in PMC

References

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