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. 1977 Jun;16(3):827-31.
doi: 10.1128/iai.16.3.827-831.1977.

Evidence for a mouse pathogenicity locus in certain temperature-sensitive mutants of foot-and-mouth disease virus

J Y Richmond

Evidence for a mouse pathogenicity locus in certain temperature-sensitive mutants of foot-and-mouth disease virus

J Y Richmond. Infect Immun. 1977 Jun.

Abstract

Serial tissue culture passaging of three foot-and-mouth disease temperature-sensitive mutants demonstrated the stability of their temperature sensitivity and mouse avirulence characteristics. Recovery of mouse-virulent temperature-sensitive viruses after passage of the mutants in mice suggested that these were not covariant expressions of the same locus, but were under the control of different genes.

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