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. 2009 Jul 31;14(8):2836-49.
doi: 10.3390/molecules14082836.

Efficient microwave assisted syntheses of 2,5-diketopiperazines in aqueous media

Lemuel Pérez-Picaso  1 , Jaime Escalante, Horacio F Olivo, María Yolanda Rios
Affiliations

Efficient microwave assisted syntheses of 2,5-diketopiperazines in aqueous media

Lemuel Pérez-Picaso et al. Molecules. .

Abstract

Aqueous in situ one-pot N-Boc-deprotection-cyclization of N alpha-Boc-dipeptidyl-tert-butyl and methyl esters under microwave irradiation afforded 2,5-diketopiperazines (DKPs) in excellent yields. This protocol is rapid, safe, environmentally friendly, and highly efficient, and showed that the tert-butoxy moiety is also an excellent leaving group for these cyclizations.

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Figures

Figure 1
Figure 1
Structure of cyclo[N-(Lys-Phe)-Orn-Val] (1).
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