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. 2009 Jul 31;14(8):2850-6.
doi: 10.3390/molecules14082850.

(+)-N-(2-hydroxypropyl)lindcarpine: a new cytotoxic aporphine isolated from Actinodaphne pruinosa Nees

Tiah Rachmatiah  1 , Mat Ropi Mukhtar, Mohd Azlan Nafiah, Muhammad Hanafi, Soleh Kosela, Hiroshi Morita, Marc Litaudon, Khalijah Awang, Hanita Omar, A Hamid A Hadi
Affiliations

(+)-N-(2-hydroxypropyl)lindcarpine: a new cytotoxic aporphine isolated from Actinodaphne pruinosa Nees

Tiah Rachmatiah et al. Molecules. .

Abstract

Onenewalkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1),together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC(50 )value of 3.9 microg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.

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Figures

Figure 1
Figure 1
Alkaloids 1- 5 isolated from Actinodaphne pruinosa.
Figure 2
Figure 2
13C-NMR spectrum of alkaloid 1.
Figure 3
Figure 3
COSY spectrum of alkaloid 1.
Figure 4
Figure 4
HMQC spectrum of alkaloid 1.
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