Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Sep;9(9):631-43.
doi: 10.1038/nrc2713.

Biological determinants of endocrine resistance in breast cancer

Elizabeth A Musgrove  1 , Robert L Sutherland
Affiliations
Review

Biological determinants of endocrine resistance in breast cancer

Elizabeth A Musgrove et al. Nat Rev Cancer. 2009 Sep.

Abstract

Endocrine therapies targeting oestrogen action (anti-oestrogens, such as tamoxifen, and aromatase inhibitors) decrease mortality from breast cancer, but their efficacy is limited by intrinsic and acquired therapeutic resistance. Candidate molecular biomarkers and gene expression signatures of tamoxifen response emphasize the importance of deregulation of proliferation and survival signalling in endocrine resistance. However, definition of the specific genetic lesions and molecular processes that determine clinical endocrine resistance is incomplete. The development of large-scale computational and genetic approaches offers the promise of identifying the mediators of endocrine resistance that may be exploited as potential therapeutic targets and biomarkers of response in the clinic.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1566-71 - PubMed
    1. Endocr Relat Cancer. 2003 Jun;10(2):179-86 - PubMed
    1. Vitam Horm. 2005;71:201-37 - PubMed
    1. Cancer Res. 2002 Dec 1;62(23):6916-23 - PubMed
    1. FASEB J. 2007 Dec;21(14):4013-27 - PubMed

Publication types

MeSH terms

Substances