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. 1990 Apr;5(4):615-8.

Similar early gene responses to ligand-activated EGFR and neu tyrosine kinases in NIH3T3 cells

P Koskinen  1 , H Lehväslaiho, H MacDonald-Bravo, K Alitalo, R Bravo
Affiliations
  • PMID: 1970155

Similar early gene responses to ligand-activated EGFR and neu tyrosine kinases in NIH3T3 cells

P Koskinen et al. Oncogene. 1990 Apr.

Abstract

We have compared the responses of serum-inducible immediate early genes to ligand activation of the epidermal growth factor receptor (EGFR) or a hybrid EGFR/neu receptor containing the intracellular domain of the neu proto-oncogene. Few differences in mRNA induction kinetics were found, emphasizing the functional similarity of these structurally related tyrosine kinases.

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