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. 2010 Mar;4(1):73-4.
doi: 10.1007/s12079-009-0061-7. Epub 2009 Aug 24.

Getting to the heart of the matter: CCN2 plays a role in cardiomyocyte hypertrophy

Andrew Leask  1
Affiliations

Getting to the heart of the matter: CCN2 plays a role in cardiomyocyte hypertrophy

Andrew Leask. J Cell Commun Signal. 2010 Mar.

Abstract

Connective tissue growth factor (CTGF/CCN2) is overexpressed in diabetes. Diabetic rats possess myocardial and cardiomyocyte hypertrophy. In a recent report, Wang and colleagues (Am J Physiol Cell Physiol. 2009 Jul 22. [Epub ahead of print]) show that CCN2 directly mediates cardiomyocyte hypertrophy as well as that induced by high glucose and fatty acid. CCN2 acted via the TrkA receptor. These data are the subject of this commentary, and emphasize that CCN2 may be an excellent target for therapy in diabetes.

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