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Comparative Study
. 2009 Dec;32(6):364-71.
doi: 10.1007/s10753-009-9144-0.

Activation of PPAR-gamma by carbon monoxide from CORM-2 leads to the inhibition of iNOS but not COX-2 expression in LPS-stimulated macrophages

Konstantin Tsoyi  1 , Yu Mi Ha, Young Min Kim, Young Soo Lee, Hyo Jung Kim, Hye Jung Kim, Han Geuk Seo, Jae Heun Lee, Ki Churl Chang
Affiliations
Comparative Study

Activation of PPAR-gamma by carbon monoxide from CORM-2 leads to the inhibition of iNOS but not COX-2 expression in LPS-stimulated macrophages

Konstantin Tsoyi et al. Inflammation. 2009 Dec.

Abstract

The effect of CO on the expression of iNOS and COX-2 was investigated by using a CO-releasing molecule (CORM)-2 in LPS-activated RAW 264.7 cells in vitro. Interestingly, CORM-2 significantly inhibited iNOS (NO) but not COX-2 (PGE(2)) expression. PPAR-gamma activators such as troglitazone, GW1929, and 15-deoxy-Delta12, 14- prostaglandin J(2) showed preferential inhibitory effect on iNOS over COX-2 expression in LPS-activated macrophages. The same effect was shown in lung tissues (iNOS, COX-2) and serum (NO, PGE(2)) when administered of CORM-2 in LPS-induced septic mice, indicating that CO derived from CORM-2 differentially regulates iNOS and COX-2 through PPAR-gamma activation under inflammation state.

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References

    1. Biochem Biophys Res Commun. 2008 Mar 14;367(3):674-9 - PubMed
    1. FASEB J. 2004 May;18(7):854-6 - PubMed
    1. J Clin Invest. 2008 Jan;118(1):239-47 - PubMed
    1. Curr Pharm Des. 2008;14(5):465-72 - PubMed
    1. J Biol Chem. 1994 Feb 18;269(7):4705-8 - PubMed

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