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Comment
. 2009 Aug 25;19(16):R683-4.
doi: 10.1016/j.cub.2009.07.025.

Notch signalling: receptor cis-inhibition to achieve directionality

David del Alamo  1 , François Schweisguth
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Comment

Notch signalling: receptor cis-inhibition to achieve directionality

David del Alamo et al. Curr Biol. .
Free article

Abstract

Lateral inhibition, by which single cells become distinct from their neighbours, can be mediated by Notch signalling during animal development. Signalling directionality is presumably achieved by downregulation of the Notch ligand in signal-receiving cells. New evidence suggests that cis-inhibition of the receptor in the ligand-sending cell might also provide directionality.

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