Review
doi: 10.1016/0167-5699(90)90016-3.
Do CD2 and CD3-TCR T-cell activation pathways function independently?
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- PMID: 1970736
- DOI: 10.1016/0167-5699(90)90016-3
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Review
Do CD2 and CD3-TCR T-cell activation pathways function independently?
Immunol Today.
1990 Feb.
Erratum in
- Immunol Today 1990 May;11(5):185
Abstract
T cells can be activated either through the CD3-T-cell receptor (TCR) complex or through CD2 (the sheep erythrocyte receptor) via an 'alternate' pathway. A number of studies have suggested that these pathways are linked. Here, Dieter Kabelitz discusses recent advances in understanding the mechanism of T-cell activation, focusing on findings that indicate that certain T cells do not express CD2. The identification of CD2-negative T cells opens a new approach for studying the interrelationship between CD3-TCR and CD2 T-cell activation pathways.
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