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. 2008 Mar;2(1):53-9.
doi: 10.2147/btt.s1519.

Bevacizumab in the therapy for refractory metastatic colorectal cancer

Mary F Mulcahy  1
Affiliations

Bevacizumab in the therapy for refractory metastatic colorectal cancer

Mary F Mulcahy. Biologics. 2008 Mar.

Abstract

Colorectal cancer is the second most common cause of cancer related deaths in the United States. Recent developments have led to prolonged survival with the use of sequential lines of chemotherapy agents. The addition of bevacizumab to active chemotherapy has further improved survival when used in the first and second lines of therapy for metastatic colorectal cancer. Evidence supporting the continued use of bevacizumab throughout lines of therapy is accumulating. Clinical trials are underway in which bevacizumab is continued beyond the first line of a chemotherapy and bevacizumab combination regimen. The mechanism by which colorectal cancer may become resistant to bevacizumab is poorly understood. Molecular and biochemical correlates which may identify bevacizumab resistance are an important component in the design of these clinical trials.

Keywords: bevacizumab; colorectal cancer; refractory.

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Figures

Figure 1
Figure 1
S0600/iBET schema: irinotecan and cetuximab with or without bevacizumab in treating patients with metastatic colorectal cancer that progressed during first-line therapy.
See this image and copyright information in PMC

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