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. 2009 Oct;86(4):438-41.
doi: 10.1038/clpt.2009.166. Epub 2009 Aug 26.

Imaging and biomarkers in early Alzheimer's disease and mild cognitive impairment

R C Petersen  1 , C R Jack Jr
Affiliations

Imaging and biomarkers in early Alzheimer's disease and mild cognitive impairment

R C Petersen et al. Clin Pharmacol Ther. 2009 Oct.

Abstract

A major focus of research on aging and dementia pertains to the prediction of future cognitive decline. Toward this end, several longitudinal studies are under way that are designed to explore early predictors of cognitive impairment. Neuroimaging techniques and biomarkers have shown promise in this application. Ultimately, it is likely that the use of a combination of neuroimaging and chemical biomarkers will be involved in predicting the development of dementia and Alzheimer's disease (AD).

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Figures

Figure 1
Figure 1
Theoretical time course of amyloid deposition relative to subsequent neurodegeneration and cognitive decline.
Figure 2
Figure 2
11C PiB scan and MRI scans for an AD subject and a healthy control subject. The 11C PiB scan shows amyloid tracer retention in the red and yellow areas and no tracer retention in the control subject. The MRI scan for the AD subject shows generalized atrophy with more focal accentuation in the hippocampus. The MRI scan for the control subject shows age related changes.
See this image and copyright information in PMC

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