Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Aug:256 Suppl 3:310-6.
doi: 10.1007/s00415-009-5242-z.

Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients

Oliver Cooper  1 , Arnar Astradsson, Penny Hallett, Harold Robertson, Ivar Mendez, Ole Isacson
Affiliations
Free article
Review

Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients

Oliver Cooper et al. J Neurol. 2009 Aug.
Free article

Abstract

Postmortem analyses from clinical neural transplantation trials of several subjects with Parkinson's disease revealed surviving grafted dopaminergic neurons after more than a decade. A subset of these subjects displayed isolated dopaminergic neurons within the grafts that contained Lewy body-like structures. In this review, we discuss why this isolated cell damage is unlikely to affect the overall graft function and how we can use these observations to help us to understand age-related neurodegeneration and refine our future cell replacement therapies.

PubMed Disclaimer

References

    1. J Clin Invest. 2009 Jan;119(1):13-5 - PubMed
    1. N Engl J Med. 1995 Apr 27;332(17):1118-24 - PubMed
    1. Brain. 2005 Jul;128(Pt 7):1498-510 - PubMed
    1. Parkinsonism Relat Disord. 2008;14 Suppl 2:S112-5 - PubMed
    1. Ann Neurol. 2003;53 Suppl 3:S135-46; discussion S146-8 - PubMed

MeSH terms