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. 1990 May;46(5):956-62.

Allelic associations of multiple RFLPs of the gene encoding complement protein C2

Z B Zhu  1 , J E Volanakis
Affiliations

Allelic associations of multiple RFLPs of the gene encoding complement protein C2

Z B Zhu et al. Am J Hum Genet. 1990 May.

Abstract

The gene for the second component of complement, C2, maps within the class III region of the major histocompatibility complex (MHC). Many human diseases have been reported to be associated with MHC alleles, haplotypes, or extended haplotypes, but in most cases additional polymorphic markers are needed for the eventual localization of the genes responsible for these diseases. In this study, nine C2 haplotypes for four restriction-site polymorphisms, detected by SstI, BamHI, and TaqI, were defined among 143 unrelated individuals. Two of these polymorphisms are multiallelic and map near the 5' end of the C2 gene. The extensive allelic variation of the C2 gene may prove of value in studies of diseases associated with the MHC.

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References

    1. Nature. 1984 Jan 19-25;307(5948):237-41 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Oct;86(20):8015-9 - PubMed
    1. Anal Biochem. 1984 May 1;138(2):267-84 - PubMed
    1. J Clin Invest. 1984 Aug;74(2):634-8 - PubMed
    1. Immunogenetics. 1984;20(4):407-15 - PubMed

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