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Case Reports
. 2009 Oct 1;49(7):1080-2.
doi: 10.1086/605576.

Pharmacokinetics of moxifloxacin in cerebrospinal fluid and plasma in patients with tuberculous meningitis

J W C Alffenaar  1 , R van Altena, H J Bökkerink, G J Luijckx, D van Soolingen, R E Aarnoutse, T S van der Werf
Affiliations
Case Reports

Pharmacokinetics of moxifloxacin in cerebrospinal fluid and plasma in patients with tuberculous meningitis

J W C Alffenaar et al. Clin Infect Dis. .

Abstract

Moxifloxacin cerebrospinal fluid (CSF) penetration was evaluated by obtaining full plasma and CSF time concentration curves for 4 patients with tuberculous meningitis. The geometric mean ratio of the areas under the curve for CSF to plasma were 0.82 (range, 0.70-0.94) at 400 mg once per day and 0.71 (0.58-0.84) at 800 mg once per day.

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