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Editorial
. 2009 Aug 28;105(5):406-7.
doi: 10.1161/CIRCRESAHA.109.205203.

Look who's talking: FGFs and BMPs in the proepicardium

Editorial

Look who's talking: FGFs and BMPs in the proepicardium

Eric C Svensson. Circ Res. .
No abstract available

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Figures

Figure 1
Figure 1. Crosstalk between FGF and BMP Signaling Pathways during Proepicardial Differentiation
Proepicardial cells, likely a heterogeneous population (as indicated by shading), differentiate down the cardiomyocyte lineage in response to BMP signaling or down a non-cardiomyocyte cardiac lineage in response to FGF signaling. Further, the FGF signaling pathway is dominant over the BMP pathway as FGF signaling through ERK can block BMP-induced cardiomyocyte differentiation.

Comment on

References

    1. Lepilina A, Coon AN, Kikuchi K, Holdway JE, Roberts RW, Burns CG, Poss KD. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell. 2006;127(3):607–619. - PubMed
    1. Olivey HE, Compton LA, Barnett JV. Coronary vessel development: the epicardium delivers. Trends in Cardiovascular Medicine. 2004;14(6):247–251. - PubMed
    1. Ishii Y, Langberg JD, Hurtado R, Lee S, Mikawa T. Induction of proepicardial marker gene expression by the liver bud. Development. 2007;134(20):3627–3637. - PubMed
    1. Watt AJ, Battle MA, Li J, Duncan SA. GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. Proc Natl Acad Sci USA. 2004;101(34):12573–12578. - PMC - PubMed
    1. Mikawa T, Fischman DA. Retroviral analysis of cardiac morphogenesis: discontinuous formation of coronary vessels. Proc Natl Acad Sci USA. 1992;89(20):9504–9508. - PMC - PubMed

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