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. 2009 Aug;5(8):e1000471.
doi: 10.1371/journal.ppat.1000471. Epub 2009 Aug 28.

Hsp90 orchestrates stress response signaling governing fungal drug resistance

Leah E Cowen  1
Affiliations

Hsp90 orchestrates stress response signaling governing fungal drug resistance

Leah E Cowen. PLoS Pathog. 2009 Aug.
No abstract available

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Conflict of interest statement

The author has declared that no competing interests exist.

Figures

Figure 1
Figure 1. Hsp90's role in fungal drug resistance.
Compromising Hsp90 function enhances the activity of fungistatic antifungal drugs, creating fungicidal drug combinations, and can block the evolution of drug resistance. Middle panel, left column indicates that in a wild-type fungal cell (shown in yellow) Hsp90 stabilizes calcineurin, enabling calcineurin-dependent stress responses that are required to survive exposure to fungistatic antifungal drugs (azoles and echinocandins for C. albicans and echinocandins for A. fumigatus). Middle panel, right column indicates that compromising Hsp90 function abrogates calcineurin-dependent stress responses, rendering fungistatic agents fungicidal (dead fungal cell shown in grey). Top panel, in S. cerevisiae, a rapid selection regime favors the emergence of Hsp90-dependent azole resistance (orange fungal cell with dashed perimeter to indicate that resistance is contingent upon Hsp90-mediated stress responses). Bottom panel, in S. cerevisiae, a gradual selection regime favors the emergence of Hsp90-independent resistance (orange fungal cell with solid perimeter).
See this image and copyright information in PMC

References

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