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. 2009 Aug;5(8):e1000406.
doi: 10.1371/journal.ppat.1000406. Epub 2009 Aug 28.

Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus

Gennadiy Zelinskyy  1 , Kirsten Dietze, Tim Sparwasser, Ulf Dittmer
Affiliations

Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus

Gennadiy Zelinskyy et al. PLoS Pathog. 2009 Aug.
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Cytotoxic CD8+ T cell responses and spleen viral loads in mice infected with FV and experimentally depleted of Tregs.
DEREG mice were infected with FV and Tregs were depleted starting at the time point of infection by five injections (days 0, 2, 4, 6, and 8 postinfection) of DT. Ten days post infection, shortly after the peak of viral replication, CD8+ T cell responses and viral loads in the spleen were analyzed. In all panels, FV-infected DEREG mice receiving DT (+DT, black bars) are compared with infected DEREG mice in which Tregs were not ablated (white bars). Statistically significant differences were calculated by the non-parametric t test and p-values are given in the figures. Six mice per group were analyzed in two independent experiments. (A) Absolute numbers of activated CD8+ T cells expressing the effector cell marker CD43 (over 90% of these cells were also positive for CD44 and negative for CD62L, confirming their effector phenotype [unpublished data]). (B) Absolute numbers of activated CD8+ T cells specific for an epitope in the FVgag gene (tetramer+). (C and D) Absolute numbers of CD8+ T cells expressing granzyme A or B, respectively. (E) Absolute numbers of CD8+ T cells expressing CD107a. (F) Spleen viral loads determined by an infectious center assay .
See this image and copyright information in PMC

References

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