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Clinical Trial
. 1990 Jan-Feb;38(1-2):45-9.

[Multicenter study of the effectiveness and tolerance of clotiazepam in cardiology]

[Article in Italian]
L Colonna  1 , F Cozzi, F Del Citerna, A Di Benedetto, O De Divitiis, F Furlanello, F Milazzotto, M Pittalis, A Taccola
Affiliations
  • PMID: 1971433
Clinical Trial

[Multicenter study of the effectiveness and tolerance of clotiazepam in cardiology]

[Article in Italian]
L Colonna et al. Minerva Cardioangiol. 1990 Jan-Feb.

Abstract

In a phase IV study with clotiazepam 9 cardiologists were involved to treat 86 patients (52 female, 32 male, mean age 51 years) effected by cardiovascular diseases and anxiety. The dosage was 5-10 mg TID, and the treatment lasted for 3 weeks. Variations of the dosage were requested in 21% of patients and generally at the 2nd week of treatment. The safety of clotiazepam was good: only in the 14% of patients side-effects were observed (especially drowsiness 9.3% and asthenia 2.3%). Clotiazepam was judged to be effective in 75% of patients. The Hamilton psychiatric rating scale for anxiety showed a progressive decrease both of the total score and of the scores of every item; the cardiovascular symptoms particularly improved at both the controls.

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