Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Nov;18(9):1219-37.
doi: 10.1007/s11136-009-9530-y. Epub 2009 Aug 28.

SF-36 includes less Parkinson Disease (PD)-targeted content but is more responsive to change than two PD-targeted health-related quality of life measures

Carlos A Brown  1 , Eric M Cheng, Ron D Hays, Stefanie D Vassar, Barbara G Vickrey
Affiliations

SF-36 includes less Parkinson Disease (PD)-targeted content but is more responsive to change than two PD-targeted health-related quality of life measures

Carlos A Brown et al. Qual Life Res. 2009 Nov.

Abstract

Objective: To compare validity including responsiveness, and internal consistency reliability and scaling assumptions of a generic (SF-36) and Parkinson Disease (PD)-targeted (PDQ-39; PDQUALIF) health-related quality of life (HRQOL) measures.

Methods: Ninety-six PD patients were administered for all HRQOL measures by telephonic interview at baseline and 18 months. Relative efficiency and responsiveness were compared relative to four external criteria (self-ratings of PD's daily effects, global Quality of Life, PD symptom severity, and a depression screener). We examined whether PD-targeted measures explained unique variance beyond the SF-36 by regressing criterion variables on HRQOL scales/items. Adequacy of PD-targeted measures' original scaling was explored by item-scale correlations.

Results: Relative efficiency estimates were similar for generic and PD-targeted measures across all criteria. Responsiveness analyses showed that the SF-36 yielded large (>0.8) effect sizes (ES) for three of eight scales for each of two criterion variables, compared to only one large ES for any scale in either PD-targeted measure. Adjusted R(2) increased from 14 to 27% in regression models that included PD-targeted items compared to models with only SF-36 scales. Item-scale correlations showed significant cross-loading of items across scales of the PD-targeted measures.

Conclusions: SF-36 responsiveness was better than that of two PD-targeted measures, yet those measures had content that significantly explains PD patients' HRQOL.

PubMed Disclaimer

References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1056/NEJMcp043908', 'is_inner': False, 'url': 'https://doi.org/10.1056/nejmcp043908'}, {'type': 'PubMed', 'value': '16148287', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/16148287/'}]}
    2. Nutt, J. G., & Wooten, G. F. (2005). Diagnosis and initial management of Parkinson’s disease. New England Journal of Medicine,353(10), 1021. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1056/NEJM199810153391607', 'is_inner': False, 'url': 'https://doi.org/10.1056/nejm199810153391607'}, {'type': 'PubMed', 'value': '9770561', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/9770561/'}]}
    2. Lang, A. E., & Lozano, A. M. (1998). Parkinson’s disease-second of two parts. New England Journal of Medicine,339(16), 1130. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1023/A:1008823222574', 'is_inner': False, 'url': 'https://doi.org/10.1023/a:1008823222574'}, {'type': 'PubMed', 'value': '10472154', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/10472154/'}]}
    2. Damiano, A. M., Snyder, C., Strausser, B., & Willian, M. K. (1999). A review of health-related quality-of-life concepts and measures for Parkinson’s disease. Quality of Life Research,8(3), 235–243. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '12959329', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/12959329/'}]}
    2. Ustun, T. B., Chatterji, S., Bickenbach, J., Kostanjsek, N., & Schneider, M. (2003). The international classification of functioning, disability and health: A new tool for understanding disability and health. Disability and Rehabilitation,25(11–12), 565–571. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1053/apmr.2002.36837', 'is_inner': False, 'url': 'https://doi.org/10.1053/apmr.2002.36837'}, {'type': 'PubMed', 'value': '12474166', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/12474166/'}]}
    2. Hays, R. D., Hahn, H., & Marshall, G. (2002). Use of the SF-36 and other health-related quality of life measures to assess persons with disabilities. Archives of Physical Medicine and Rehabilitation,83(12 Suppl 2), S4–S9. - PubMed

Publication types