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Clinical Trial
. 2009 Dec;107(3):202-7.
doi: 10.1016/j.ijgo.2009.07.037. Epub 2009 Aug 28.

Effect of prenatal and perinatal antibiotics on maternal health in Malawi, Tanzania, and Zambia

Said Aboud  1 , Gernard Msamanga, Jennifer S Read, Lei Wang, Chelu Mfalila, Usha Sharma, Francis Martinson, Taha E Taha, Robert L Goldenberg, Wafaie W Fawzi
Affiliations
Clinical Trial

Effect of prenatal and perinatal antibiotics on maternal health in Malawi, Tanzania, and Zambia

Said Aboud et al. Int J Gynaecol Obstet. 2009 Dec.

Abstract

Objective: We assessed the effect of prenatal and peripartum antibiotics on maternal morbidity and mortality among HIV-infected and uninfected women.

Methods: A multicenter trial was conducted at clinical sites in 4 Sub-Saharan African cities: Blantyre and Lilongwe, Malawi; Dar es Salaam, Tanzania; and Lusaka, Zambia. A total of 1558 HIV-infected and 271 uninfected pregnant women who were eligible to receive both the prenatal and peripartum antibiotic/placebo regimens were enrolled. Pregnant women were interviewed at 20-24 weeks of gestation and a physical examination was performed. Women were randomized to receive either antibiotics or placebo. At the 26-30 week visit, participants were given antibiotics or placebo to be taken every 4 hours beginning at the onset of labor and continuing after delivery 3 times a day until a 1-week course was completed. Logistic regression and Cox proportional hazards models were used.

Results: There were no significant differences between the antibiotic and placebo groups for medical conditions, obstetric complications, physical examination findings, puerperal sepsis, and death in either the HIV-infected or the uninfected cohort.

Conclusion: Administration of study antibiotics during pregnancy had no effect on maternal morbidity and mortality among HIV-infected and uninfected pregnant women.

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Conflict of interest statement

Conflict of interest

The conclusions and opinions expressed in this paper are those of the authors and do not necessarily reflect those of the funding agencies and participating institutions. The authors declare that there are no conflicts of interests.

Figures

Figure 1
Figure 1
Derivation of the study population
See this image and copyright information in PMC

References

    1. Parry S, Strauss JF., 3rd Premature rupture of the fetal membranes. N Engl J Med. 1998;338(10):663–670. - PubMed
    1. Goldenberg RL, Andrews WW, Yuan A, MacKay T, St Louis M. Sexually transmitted diseases and adverse outcomes of pregnancy. Clinics in Perinatology. 1997;24:23–41. - PubMed
    1. Andrews WW, Hauth JC, Cliver SP, Savage K, Goldenberg RL. Randomized clinical trial of extended antibiotic spectrum with coverage for Ureaplasma urealyticum to reduce post-cesarean delivery endometritis. Obstet Gynecol. 2003;101(6):1183–1189. - PubMed
    1. Sebitloane HM, Moodley J, Esterhuizen TM. Prophylactic antibiotics for the prevention of postpartum infectious morbidity in women infected with human immunodeficiency virus: a randomized controlled trial. Am J Obstet Gynecol. 2008;198(2):e1–e6. 189. - PubMed
    1. Andrews WW, Sibai BM, Thom EA, Dudley D, Ernest JM, McNellis D, et al. Randomized clinical trial of metronidazole plus erythromycin to prevent spontaneous preterm delivery in fetal fibronectin-positive women. Obstet Gynecol. 2003;101(5 Pt 1):847–855. - PubMed

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