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. 1977 Sep;119(3):1106-8.

Thymosin-induced human serum factor increasing cyclic AMP

A Astaldi, G C Astaldi, P Wijermans, M Groenewoud, P T Schellekens, V P Eijsvoogel
  • PMID: 197166

Thymosin-induced human serum factor increasing cyclic AMP

A Astaldi et al. J Immunol. 1977 Sep.

Abstract

Thymosin has virtually no in vitro effect on cyclic AMP levels in thymocytes and seems not to react with either the beta-adrenergic receptor or with the putative human serum thymic factor (SF) receptor. However, when thymosin is injected into patients lacking SF activity, it induces the appearance of a serum factor which increases cellular cyclic AMP levels in thymocytes in vitro. This factor appears to act on a membrane site distinct from the beta-adrenergic receptors.

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