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. 1977 Sep;119(3):1138-44.

Macrophages are required for the dextran-sulfate induced activation of B lymphocytes

U C Persson, L L Hammarström, C I Smith
  • PMID: 197167

Macrophages are required for the dextran-sulfate induced activation of B lymphocytes

U C Persson et al. J Immunol. 1977 Sep.

Abstract

The proliferative response induced by the B cell activating ligand dextran-sulfate (DxS) requires the presence of macrophage-produced factors or the macrophage-substituting compound 2-mercaptoethanol. Thus, the mechanism for activation of mouse B splenic lymphocytes is different for DxS than for other polyclonal B cell activators such as lipopolysaccharides, which can trigger B cells directely in the absence of the helper factors. It is suggested that the disappearance of the DxS-induced response could be studied in a simple functional tests for the efficiency of macrophage depletion obtained by different techniques.

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