Kinky binding and SECsy insertions
- PMID: 19716783
- DOI: 10.1016/j.molcel.2009.08.001
Kinky binding and SECsy insertions
Abstract
Here Budiman et al. (2009) demonstrate that the selective translation of selenocysteine-containing proteins can be regulated by the mutually exclusive binding of eIF4a3 and SECIS binding protein 2 (SBP2) to a cis-acting element in the 3' untranslated region (3'UTR) of the target mRNA.
Comment on
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Eukaryotic initiation factor 4a3 is a selenium-regulated RNA-binding protein that selectively inhibits selenocysteine incorporation.Mol Cell. 2009 Aug 28;35(4):479-89. doi: 10.1016/j.molcel.2009.06.026. Mol Cell. 2009. PMID: 19716792 Free PMC article.
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